منابع مشابه
Averting danger from within
A factor that promotes blood vessel growth keeps two types of brain cells alive, say Maharaj et al. (page 491). Their findings might explain why anticancer drugs that block this factor cause neurological side effects. The drug target in question—vascular endothelial growth factor (VEGF)— binds to receptors on blood vessel endothelial cells. A localized increase in VEGF, which is produced by und...
متن کاملWith Aβ, the danger lies within
astillo et al. (page 453) have identified what may be a key event in building the spindle pole body (SPB) of budding yeast. They found that the kinase Mps1p phosphorylates and thus helps organize Spc42p, an important component of the SPB central plaque. Mps1p has been a difficult protein to study, as it does double duty as a regulator of SPB structure, and as part of the spindle checkpoint sign...
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A hormonal paradox In 1896, a physician named George Beatson controlled the growth of mammary tumors in women by simply removing their ovaries (1); he thus provided the first connection between breast cancer and the secretions of reproductive organs. But a lack of ovarian function did not guarantee a cancerfree life—breast cancer also occurred in men and older women. The identification of the o...
متن کاملEstimating Potential Fire Danger within the Siberian Tiger Habitat
Forests of the Russian Far East, designated by UNESCO as a World Heritage site and home to the Siberian tiger a highly endangered species with approximately 350 adult tigers remaining in the wild, are severely threatened by wildland fires. The frequency of catastrophic fire events is predicted to rise due to global warming trends. The large size and mountainous terrain of the study area and gov...
متن کاملAsthma is a Serious Danger
میزان مرگ و میر آسم طی دهه گذشته بطور چشمگیری تغییر کرده است. با مبتلا کردن ۱۵ میلیون آمریکایی میزان مرگ و میر در سال ۱۹۷۸، به رقم ۱۸۷۲ نفر و ۹ سال بعد، به بیش از ۴۰۰۰ نفر رسید. علت چنین افزایش چشمگیری روشن نیست. علل احتمالی عبارتند از کاهش ظرفیت تنفس، استفاده بیش از حد از داروهای استثنائی و استنباط غلط بیماران و نیز مراکز درمانی نسبت به شدت بیماری است. بررسی دقیق، معالجات مناسب و آموزش به ب...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2008
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2052iti4